Herbicides

A study investigated whether cytogenetic damage increased through prolonged pesticide exposure in n = 117 children, aged 7-11 years, living in rural areas of intensive agriculture; controls being n = 87 children from an agri-tourism region without pesticide exposure. DNA Single-Strand Breaks (SSB) were detected by the Comet assay in whole fresh blood samples together with ‘formamidopyrimidine DNA-glycosylase (FPG)-sensitive sites' with the bacterial FPG protein in isolated lymphocytes. Micronuclei (MN) levels were measured by the cytokinesis-block MN assay. Acetylcholinoesterase (AChE) and Pseudocholinesterase (PChE) activities were used as biomarkers of exposure. Subjects exposed to pesticides had significantly higher AChE and PChE activities than controls, although average levels were well below the biological exposure limit. In addition, those exposed to pesticides had significantly higher levels of steady-state FPG sites and SSB levels (p < 0.001), as well as MN levels. A positive correlation was found between PChE activity and FPG-sensitive sites and also between MN levels and FPG-sensitive sites, (both p < 0.01). In conclusion, despite the relatively low pesticide exposures in the test group of children, significant biological/developmental effects were detected.

Carlos Jusino grew up a typical kid in Harlem, rollerblading near the Hudson River, eating at the McDonald's on 145th Street and Broadway, hanging out with friends in his building. Also typical was the fact that many of Jusino's neighbors and family members, including his mother, had asthma. "When I was growing up, she went to the hospital about once a month for asthma," he says. Although he didn't know it at the time, more than 30 percent of the kids in Harlem have asthma, one of the highest rates in the country. Jusino's family was worried about the air quality around Harlem, but most of its attention was directed to a sewage treatment facility built in 1985 along the West Side Highway next to the Hudson, where a foul-smelling settling tank lay exposed. The plant galvanized the community, including a group of environmental justice activists known as the Sewage Seven. They sued the city and won a settlement in 1994 that helped establish air-monitoring stations around the plant.

The biotech sector often yells for “peer review” when the anti-GMO movement refers to analyses or research-based findings to state its case. Despite Professor Seralini publishing his research findings (rats fed on GMOs) that were critical of the health impacts of GMOs in an internationally renowned peer-reviewed journal in 2012, his methodology and findings were nevertheless subjected to sustained attacks by the sector. Personal smears came his way too (1). Now he finds that his paper has been retracted by the journal. Peer review or no peer review, it seems to matter little to the biotech sector when research findings have the potential to damage its interests. In any case, peer review is only for the sector's critics. It doesn't seem to apply much to it. For instance, in the US Food and Drug Administration (FDA) scientists had continually warned regulators that GM crops could create unpredictable and hard to detect side effects, including allergies, toxin production, nutritional problems, and new diseases. They recommended that long-term studies were needed to fully assess the effect of GM foods on other crops, the ecosystem, and animal and human health, but these warnings were ignored (2).

This letter is in response to Julee Boan’s excellent article about Ontario’s Endangered Species Act (Paying the Interest, Ignoring the Debt — CJ, Nov. 29). This act is extremely important and we ignore it at our peril. In towns and cities we have animal humane societies that ensure that the animals under our care in our homes are given the best protection we can offer. The animals, fish and insects in our wilderness are no less deserving. The act should be their voice to protect them from the harmful impacts of mining, fossil-fuel extraction, forestry, fishing and farming, not for the protection of these same industries. These impacts are real and can be devastating. Two examples from farming have come to my attention lately. Both were preventable.

Un estudio reciente evidenció que las células neuronales tratadas con el herbicida glifosato muestran un desarrollo más lento. Estas células fueron obtenidas del cerebro de embriones de ratas en un estudio in vitro, según divulgación de la Universidad Nacional de Rosario. Las investigaciones se realizaron en vivo con animales que se expusieron al herbicida e in vitro directamente con las neuronas del cerebro de embriones de ratas, los cuales se trataron con diferentes dosis, que están por debajo de la graduación a la que se expone el ser humano en los espacios donde se aplica el herbicida. El análisis de los resultados arrojó que el glifosato en las dosis estudiadas no produce letalidad, sin embargo las células se desarrollan mucho más lentamente. "Una neurona que tiene cuatro días, morfológicamente es una neurona de uno o dos días”, señaló en un comunicado Silvana Rosso, investigadora adjunta de CONICET y docente del Área Toxicología de la Facultad de Cs. Bioquímicas y Farmacéuticas de la Universidad Nacional de Rosario (UNR).

At first glance the frozen bundles could be mistaken for conventional joints of meat. But as Ib Pedersen, a Danish pig farmer, lifts them carefully out of the freezer it becomes apparent they are in fact whole piglets - some horribly deformed, with growths or other abnormalities, others stunted. This is the result, Pedersen claims, of feeding the animals a diet containing genetically modified (GM) ingredients. Or more specifically, he believes, feed made from GM soya and sprayed with the controversial herbicide glyphosate. Pedersen, who produces 13,000 pigs a year and supplies Europe's largest pork company Danish Crown, says he became so alarmed at the apparent levels of deformity, sickness, deaths, and poor productivity he was witnessing in his animals that he decided to experiment by changing their diet from GM to non-GM feed. The results, he says, were remarkable: "When using GM feed I saw symptoms of bloat, stomach ulcers, high rates of diarrhoea, pigs born with the deformities ... but when I switched [to non GM feed] these problems went away, some within a matter of days." The farmer says that not only has the switch in diet improved the visible health of the pigs, it has made the farm more profitable, with less medicine use and higher productivity. "Less abortions, more piglets born in each litter, and breeding animals living longer." He also maintains that man hours have been reduced, with less cleaning needed and fewer complications with the animals.

A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk.