Dose: Time-to-effect analyses can identify hazardous chemicals at an early stage of product development
Expenditure for discovery and development of a new crop protection product is now approaching the $ 300 million mark, while at the same time underpinning information gaps in environmental safety assessment. Large information gaps also exist for the safety of a vast number of existing chemicals in commerce. Addressing safety information gaps of new and existing chemicals with increased conventional toxicity testing would skyrocket costs and animal usage and contravene the 3Rs principles to refine, reduce, and replace animal testing.